國家衛生研究院 NHRI:Item 3990099045/3585
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    题名: Conditioning vaccination site with irradiated MIP-3alpha-transfected tumor cells enhances efficacy of dendritic cell-based cancer vaccine
    其它题名: Conditioning vaccination site with irradiated MIP-3α-transfected tumor cells enhances efficacy of dendritic cell-based cancer vaccine
    作者: Shih, NY;Yang, HY;Cheng, HT;Hung, YM;Yao, YC;Zhu, YH;Wu, YC;Liu, KJ
    贡献者: National Institute of Cancer Research
    摘要: Macrophage inflammation protein-3α (MIP-3α) is a chemokine expressed in inflamed tissue and capable of inducing migration of immature dendritic cells (DCs) or Langerhans cells. We postulated that conditioning vaccination sites with MIP-3α might enhance the efficacy of subsequently administered DC-based cancer vaccines. Our results demonstrate that subcutaneously injection of irradiated tumor cells expressing MIP-3α induces substantial cell infiltration to the injection site. Vaccination of irradiated tumor cells expressing MIP-3α followed by DCs pulsed with irradiated tumor cells can effectively suppress tumor growth in animals, which is significantly better than vaccination with irradiated MIP-3α-producing tumor cells or DCs pulsed with tumor cells alone. The protective effect was most evident when the MIP-3α-producing tumor cells and DC-based vaccines were injected at the same site. These results support the notion that this combination vaccination strategy might generate a more effective immune response to suppress the growth of tumor cells in animals.
    日期: 2009-05
    關聯: Journal of Immunotherapy. 2009 May;32(4):363-369.
    Link to: http://dx.doi.org/10.1097/CJI.0b013e31819d29d8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1524-9557&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000265460700005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67449101536
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