國家衛生研究院 NHRI:Item 3990099045/3553
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 855385      在线人数 : 1069
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3553


    题名: Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors
    作者: Tsai, TY;Hsu, T;Chen, CT;Cheng, JH;Yeh, TK;Chen, X;Huang, CY;Chang, CN;Yeh, KC;Hsieh, SH;Chien, CH;Chang, YW;Huang, CH;Huang, YW;Huang, CL;Wu, SH;Wang, MH;Lu, CT;Chao, YS;Jiaang, WT
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: A series of trans-2-aryl-cyclopropylamine derived compounds were synthesized and evaluated their biological activities against DPP-IV. The structure-activity relationships (SAR) led to the discovery of novel series of DPP-IV inhibitors, having IC50 values of <100 nM with excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. The studies identified a potent and selective DPP-IV inhibitor 24b, which exhibited the ability to both significantly inhibit plasma DPP-IV activity in rats and improve glucose tolerance in lean mice and diet induced obese mice.
    日期: 2009-03-15
    關聯: Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399.
    Link to: http://dx.doi.org/10.1016/j.bmc.2009.02.020
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0968-0896&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000264236700032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=62549138270
    显示于类别:[蔣維棠] 期刊論文
    [葉燈光] 期刊論文
    [陳新(2002-2015)] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳炯東] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP62549138270.pdf555KbAdobe PDF1187检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈