國家衛生研究院 NHRI:Item 3990099045/3545
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    题名: Near-infrared mesoporous silica nanoparticles for optical imaging: Characterization and in vivo biodistribution
    作者: Lee, CH;Cheng, SH;Wang, YJ;Chen, YC;Chen, NT;Souris, J;Chen, CT;Mou, CY;Yang, CS;Lo, LW
    贡献者: Division of Medical Engineering Research;Center for Nanomedicine Research
    摘要: The characterization of near-infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN-TA) with the average size of 50-100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN-TA-ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN-TA-ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN-TA-ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN-TA-ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN-TA-ICG in major organs. This is the first report of MSN function alized with NIR-ICG capable of optical imaging in vivo. 穢 2009 WILEY-VCH Verlag GmbH & Co. KGaA.
    日期: 2009-01-23
    關聯: Advanced Functional Materials. 2009 Jan 23;19(2):215-222.
    Link to: http://dx.doi.org/10.1002/adfm.200800753
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1616-301X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000263082600004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=58949102416
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