國家衛生研究院 NHRI:Item 3990099045/3533
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    題名: Increased concentrations of serum inhibin B among male workers with long-term moderate lead exposure
    作者: Hsieh, SJ;Chiu, YW;Li, WF;Wu, CH;Chen, HI;Chuang, HY
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Lead is known to have an adverse effect to human reproductive system. This study investigates the association between different lead indices (both current and cumulative) and serum inhibin B as well as hormone concentrations in a group of 181 male lead workers. We used data collected during annual health examinations, including measurements of blood lead levels, inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (TTE) as well as age, gender, height, weight, smoking and drinking habits. The cumulative lead index included index of cumulative blood lead (ICL) and time weighted index of cumulative blood lead (TWICL) which were calculated from the series blood lead concentrations by annual health examinations since 1991 to the time of the study. Data was analyzed by Pearson correlation and multiple regressions. We found the Pearson correlation coefficients of ICL and TWICL vs. inhibin B to be 0.220 (p = 0.003) and 0.231 (p = 0.008), respectively. After adjusting for age, smoking, drinking, LH, FSH, and TTE, our multiple regression models revealed that with each unit increase in ICL and TWICL, there was a 0.047?pg/mL (p = 0.017) and 1.333?pg/mL (p = 0.007) increase in inhibin B. We found an association between cumulative lead index and concentration of serum inhibin B in male workers exposed to lead over long period, possibly indirectly affecting spermatogenesis. 2008.
    日期: 2009-04-01
    關聯: Science of the Total Environment. 2009 Apr 1;407(8):2603-2607.
    Link to: http://dx.doi.org/10.1016/j.scitotenv.2008.12.056
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0048-9697&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000264922000014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=61649093742
    顯示於類別:[李婉芬(2001-2009)] 期刊論文

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