國家衛生研究院 NHRI:Item 3990099045/3493
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3493


    Title: Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia
    Authors: Hong, CC;Lay, JD;Huang, JS;Cheng, AL;Tang, JL;Lin, MT;Lai, GM;Chuang, SE
    Contributors: National Institute of Cancer Research
    Abstract: By using a novel profiling analysis of protein tyrosine kinases differentially expressed in the sensitive and refractory leukemia from the same patients we found that AXL was upregulated in drug-resistant leukemia. Furthermore, AXL could be induced by chemotherapy drugs in the acute myeloid leukemia U937 cells and this induction was dependent on the CCWGG methylation status of the AXL promoter. In U937 cells ectopically overexpressing AXL, addition of exogenous Gas6 induced AXL phosphorylation and activation of the Akt and ERK1/2 survival pathways. The Gas6-AXL activation pathway of drug resistance was associated with increased expression of Bcl-2 and Twist. These results show that upregulation of AXL by chemotherapy might induce drug resistance in acute myeloid leukemia in the presence of Gas6 stimulation. ? 2008 Elsevier Ireland Ltd. All rights reserved.
    Date: 2008-09-18
    Relation: Cancer Letters. 2008 Sep 18;268(2):314-324.
    Link to: http://dx.doi.org/10.1016/j.canlet.2008.04.017
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259898500015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=48549094691
    Appears in Collections:[Shuang-En Chuang] Periodical Articles
    [Gi-Ming Lai(2004-2008)] Periodical Articles

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