國家衛生研究院 NHRI:Item 3990099045/3472
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    题名: Gold-nanoparticle-enhanced IGG immunological detection by in-situ fabry-perot sensor
    作者: Tseng, YT;Jhuang, ST;Yang, CS;Tseng, FG
    贡献者: Center for Nanomedicine Research
    摘要: This paper proposes a needle-type biosensor for immunological application, which combines the abilities of real-time monitoring, in-situ measurement and high sensitivity, by adopting gold-nanoparticles (GNPs) coated with antibody to enhance the signal of Fabry-Perot (F-P) interferometry in an optic fiber sensing system. Strong reflection induced by larger index mismatch and longer optical path from GNPs-protein conjugation are suggested to attribute most to the signal enhancement in F-P interference shift. The experiments carry out the monitoring of immuno-sensing in real-time by the employment of rabbit IgG conjugate to GNPs-anti-rabbit IgG. And the detection limit was demonstrated to approach 0.17 nM (～25.5 ng/ml), which was three orders of magnitude better than those of the traditional fiber-based F-P biosensors. Besides, the reproducibility of the sensor has been tested through at least three cycles of detection/surface- regeneration process and demonstrated a reasonable consistency. The relationship between the concentrations of GNPs-antibody and F-P spectrum shift has also been characterized. The time-constant of this sensor to complete one cycle of biomolecule-detection and surface-regeneration can be as low as 4 minutes. ? 2007 IEEE.
    日期: 2007-01
    關聯: 20th IEEE International Conference on Micro Electro Mechanical Systems. 2007 Jan;2007:441-444.
    Link to: http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4432985
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000255867800026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52249116270
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