The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-β-lactamase- producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (1SCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.
Date:
2009-03
Relation:
Antimicrobial Agents and Chemotherapy. 2009 Mar;53(3):1235-1237.
