國家衛生研究院 NHRI:Item 3990099045/3410

NHRI > National Institute of Infectious Diseases and Vaccinology > Chia-Yu Chi > Periodical Articles > Item 3990099045/3410

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3410

Title:	Clinical features of children infected with different strains of influenza B in southern Taiwan
Authors:	Chi, CY;Wang, SM;Lin, CC;Wang, HC;Wang, JR;Su, IJ;Liu, CC
Contributors:	Division of Clinical Research
Abstract:	BACKGROUND: This study was designed to determine the clinical characteristics of children infected with different strains of influenza B viruses isolated in southern Taiwan. The clinical features were compared with influenza A infection occurring in the same period. METHODS: All children enrolled in the study had laboratory-confirmed infection with influenza A or B viruses. Influenza B speciation was performed by RNA extraction, cDNA synthesis, and amplification by polymerase chain reaction and sequencing. Demographic data, clinical findings, diagnoses, and outcomes were obtained. RESULTS: During the study period, 163 strains of influenza A and 118 strains of influenza B were isolated. The Yamagata-like strains were most prevalent in 2001. New reassortant strains were identified since 2002 and became predominant in 2005 and 2006. Children with influenza B were more likely than those with influenza A to be diagnosed as upper respiratory tract infection, myositis, and gastroenteritis (P < 0.05). Children infected with Yamagata-like strains were more likely to develop lower respiratory tract infection (P < 0.05) and accounted for all cases of invasive disease. Children infected with the Victoria-like group had the longest hospital stays associated with severe bacterial superinfection. CONCLUSIONS: Currently new reassortant influenza B viruses are the predominant strains circulating in southern Taiwan. There is considerable similarity of clinical features between influenza A and B in children. The Yamagata-like strains were associated with more invasive infections. Continuous influenza virus surveillance is essential particularly in Taiwan where pandemic strains tend to appear earlier than in other countries.
Date:	2008-07
Relation:	Pediatric Infectious Disease Journal. 2008 Jul;27(7):640-645.
Link to:	http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00006454-200807000-00011
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0891-3668&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000257176600011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=50949114784
Appears in Collections:	[Chia-Yu Chi] Periodical Articles [Ih-Jen Su(2002-2015)] Periodical Articles

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