國家衛生研究院 NHRI:Item 3990099045/3384
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3384


    题名: Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists
    作者: Chu, CM;Hung, MS;Hsieh, MT;Kuo, CW;Suja, TD;Song, JS;Chiu, HH;Chao, YS;Shia, KS
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with a 5-alkyl oxadiazole ring, a novel class of oxadiazole derivatives with promising biological activity towards CB1 receptors was discovered. Among them, compounds with an alkyl linker containing a strong electron-withdrawing group (e.g., CF3) and a sterically favorable bulky group (e.g., t-butyl) exhibited excellent CB1 antagonism and selectivity, and thus might serve as potential candidates for further development as anti-obesity agents. 穢 2008 The Royal Society of Chemistry.
    日期: 2008-09-21
    關聯: Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407.
    Link to: http://dx.doi.org/10.1039/b807648k
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259407800023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52649148140
    显示于类别:[夏克山] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [洪明秀] 期刊論文

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