國家衛生研究院 NHRI:Item 3990099045/3303
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    題名: Synthesis and characterization of positive-charge functionalized mesoporous silica nanoparticles for oral drug delivery of an anti-inflammatory drug
    作者: Lee, CH;Lo, LW;Mou, CY;Yang, CS
    貢獻者: Center for Nanomedicine Research;Division of Medical Engineering Research
    摘要: We synthesized mesoporous silica nanoparticles (MSN) with different densities of surface positive charges. The positive surface charge was generated by incorporating trimethylammonium (TA) functional groups into the framework of MSN (MSN-TA) via direct co-condensation of a TA-silane and tetraethoxysilane (TEOS) in the presence of a base as a catalyst. These MSN-TA samples have well-defined hexagonal structures with an average particle diameter of 100 nm, pore size of 2.7 nm, and surface area of about 1000 m2g-1. Anionic drug molecules, Orange II (a fluorescent tracing molecule), and sulfasalazine (an anti-inflammatory prodrug used for bowel disease), were effectively loaded into these MSN-TA samples and remained inside of the MSNTA under acidic environment (pH 2-5). The amounts of loading of both Orange II and sulfasalazine were increased with increasing positive charge densities resulting from the increasing number of TA groups. When these drug-loaded MSN-TA nanoparticles were placed in physiological buffer solution (pH 7.4), a partial negative surface charge on the MSN-TA was generated due to the deprotonation of silanol groups, and the strong electrostatic repulsion triggered a sustained release of the loaded molecules. MSN-TA as a nanovehicle for pH-dependent loading and controllable release of anionic drug molecules can be used as an oral delivery drug systems targeting at intestine. These drugs can be remained trapped in the nanovehicle when passing through the stomach's acidic environment and be released in intestine where the environmental pH is close to neutral. ?2008 WILEY-VCH Verlag GmbH & Co. KGaA.
    日期: 2008-10-23
    關聯: Advanced Functional Materials. 2008 Oct 23;18(20):3283-3292.
    Link to: http://dx.doi.org/10.1002/adfm.200800521
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1616-301X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000260707300021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=55349106227
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