國家衛生研究院 NHRI:Item 3990099045/3250

NHRI > Institute of Biomedical Engineering and Nanomedicine > Dong-Ming Huang > Periodical Articles > Item 3990099045/3250

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3250

Title:	Mesoporous silica nanoparticles as a delivery system of gadolinium for effective human stem cell tracking
Authors:	Hsiao, JK;Tsai, CP;Chung, TH;Hung, Y;Yao, M;Liu, HM;Mou, CY;Yang, CS;Chen, YC;Huang, DM
Contributors:	Center for Nanomedicine Research
Abstract:	The progress of using gadolinium (Gd)-based nanoparticles in cellular tracking lags behind that of superparamagnetic iron oxide (SPIO) nanoparticles in magnetic resonance imaging (MRI). Here, dual functional Gd-fluorescein isothiocyanate mesoporous silica nanoparticles (Gd-Dye@MSN) that possess green fluorescence and paramagnetism are developed in order to evaluate their potential as effective T1-enhancing trackers for human mesenchymal stem cells (hMSCs). hMSCs are labeled efficiently with Gd-Dye@MSN via endocytosis. Labeled hMSCs are unaffected in their viability, proliferation, and differentiation capacities into adipocytes, osteocytes, and chondrocytes, which can still be readily MRI detected. Imaging, with a clinical 1.5-T MRI system and a low incubation dosage of Gd, low detection cell numbers, and short incubation times is demonstrated on both loaded cells and hMSC-injected mouse brains. This study shows that the advantages of biocompatibility, durability, high internalizing efficiency, and pore architecture make MSNs an ideal vector of T1-agent for stem-cell tracking with MRI. ? 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Date:	2008-09
Relation:	Small. 2008 Sep;4(9):1445-1452.
Link to:	http://dx.doi.org/10.1002/smll.200701316
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1613-6810&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000259536800027
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52649172803
Appears in Collections:	[Dong-Ming Huang] Periodical Articles [Chung-Shi Yang] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP52649172803.pdf		727Kb	Adobe PDF	1551	View/Open

Loading...