國家衛生研究院 NHRI:Item 3990099045/3228
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3228


    Title: DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans
    Authors: Wang, SF;Huang, JC;Lee, YM;Liu, SJ;Chan, YJ;Chau, YP;Chong, P;Chen, YMA
    Contributors: Vaccine Research and Development Center
    Abstract: DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their ability to bind with DC-SIGN. Electronic microscopy and functional assay results indicate that pseudotyped viruses containing both HA and NA proteins express hemagglutination and are capable of infecting cells expressing α-2,3-linked sialic acid receptors. Results from a capture assay show that DC-SIGN-expressing cells (including B-THP-1/DC-SIGN and T-THP-1/DC-SIGN) and peripheral blood dendritic cells are capable of transferring H5N1 pseudotyped and RG virus particles to target cells; this action can be blocked by anti-DC-SIGN monoclonal antibodies. In summary, (a) DC-SIGN acts as a capture or attachment molecule for avian H5N1 virus, and (b) DC-SIGN mediates infections in cis and in trans.
    Date: 2008-09
    Relation: Biochemical and Biophysical Research Communications. 2008 Sep;373(4):561-566.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2008.06.078
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000258208500020
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47649092816
    Appears in Collections:[Pele Choi-Sing Chong] Periodical Articles
    [Shih-Jen Liu] Periodical Articles

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