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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3164


    Title: Mesoporous silica nanoparticles improve magnetic labeling efficiency in human stem cells
    Authors: Liu, HM;Wu, SH;Lu, CW;Yao, M;Hsiao, JK;Hung, Y;Lin, YS;Mou, CY;Yang, CS;Huang, DM;Chen, YC
    Contributors: Center for Nanomedicine Research
    Abstract: Tumblerlike magnetic/fluorescein isothiocyanate (FITC)-labeled mesoporous silica nanoparticles, Mag-Dye@MSNs, have been developed, which are composed of silica-coated core-shell superparamagnetic iron oxide (SPIO@SiO2) nanoparticles co-condensed with FITC-incorporated mesoporous silica. Mag-Dye@MSNs can label human mesenchymal stem cells (hMSCs) through endocytosis efficiently for magnetic resonance imaging (MRI) in vitro and in vivo, as manifested by using a clinical 1.5-T MRI system with requirements of simultaneous low incubation dosage of iron, low detection cell numbers, and short incubation time. Labeled hMSCs are unaffected in their viability, proliferation, and differentiation capacities into adipocytes and osteocytes, which can still be readily detected by MRI. Moreover, a higher MRI signal intensity decrease is observed in Mag-Dye@MSN-treated cells than in SPIO@SiO2-treated cells. This is the first report that MCM-41-type MSNs are advantageous to cellular uptake, as manifested by a higher labeling efficiency of Mag-Dye@MSNs than SPIO@SiO2.
    Keywords: Chemistry, Multidisciplinary;Nanoscience & Nanotechnology;Materials Science, Multidisciplinary;Physics, Applied;Physics, Condensed Matter
    Date: 2008-05
    Relation: Small. 2008 May;4(5):619-626.
    Link to: http://dx.doi.org/10.1002/smll.200700493
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1613-6810&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000256366100018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=44949136246
    Appears in Collections:[黃東明] 期刊論文
    [楊重熙] 期刊論文

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