國家衛生研究院 NHRI:Item 3990099045/3149
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    题名: Benzodiazepine and risk of hip fractures in older people: A nested case-control study in Taiwan
    作者: Chang, CM;Wu, ECH;Chang, IS;Lin, KM
    贡献者: Division of Mental Health and Substance Abuse Research;National Institute of Cancer Research
    摘要: Objective: To examine the characteristics of benzodiazepines usage and their associations with hip fractures. Method: All subjects were aged 65 and older and enrolled in the National Health Insurance program in Taiwan, 2001-2004. Cases (N = 217) were elderly patients who were identified with hip fractures for the first time in their outpatient claims. They were individually matched to 1,214 comparison patients based on age, gender, and index year. Benzodiazepine usage (doses, duration, half-life) and the other covariates including comorbidities, health care utilization, and psychotropic medications used in the 180 days before index events were constructed. Results: Using nonusers as reference group, use of benzodiazepines was significantly associated with hip fractures (adjusted odds ratio [AOR] = 1.7, 95% confidence interval [CI] = 1.2-2.5). Such risks appear to be particularly high during the first month (AOR = 5.6, 95% CI = 2.7-11.8) of exposure, doses higher than 3.0 mg/day in diazepam equivalents (AOR = 1.8, 95% CI = 1.1-3.1), and using short-acting benzodiazepines (AOR = 1.8, 95% CI = 1.3-2.7). Conclusions: Benzodiazepine exposure in the elderly increases the risk of hip fractures. This is true even with modest dosage, short-acting agents and short-term exposures. Clinicians should prescribe benzodiazepines judiciously with the elderly to minimize drug-related hip fractures.
    关键词: Geriatrics & Gerontology;Gerontology;Psychiatry
    日期: 2008-08
    關聯: American Journal of Geriatric Psychiatry. 2008 Aug;16(8):686-692.
    Link to: http://dx.doi.org/10.1097/JGP.0b013e31817c6a99
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1064-7481&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000258097300009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=54549124569
    显示于类别:[林克明(2004-2009)] 期刊論文
    [張憶壽] 期刊論文

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