國家衛生研究院 NHRI:Item 3990099045/3143
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    题名: Evidence for association between genetic variants of p75 neurotrophin receptor (p75(NTR)) gene and antidepressant treatment response in Chinese major depressive disorder
    作者: Gau, YTA;Liou, YJ;Yu, YWY;Chen, TJ;Lin, MW;Tsai, SJ;Hong, CJ
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: The p75 neurotrophin receptor (p75(NTR)) is an essential component of neurotrophin system, and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to delineate the association between phenotype (MDD susceptibility and antidepressant response) and genotype (p75(NTR) common genetic variants) in a Chinese population. A total of 228 MDD patients and 402 unrelated controls were recruited. Subjects took selective serotonin reuptake inhibitors (SSRIs) and responders were defined as those with at least a 50% decrease in score of the Hamilton Rating Scale for Depression (HAM-D) from baseline. Five p75(NTR) R polymorphisms were genotyped and their association with MDD or treatment response was assessed by haplotype and single marker analysis. No significant association with MDD was discovered in single locus or haplotype analyses. With regard to the therapeutic outcome, however, one missense polymorphism (S250L) showed association in both genotype distribution (P = 0.039) and allele frequency (P = 0.012). Haplotype analysis also revealed that p75(NTR) TCT carriers had a more unfavorable response to therapy (P = 0.010). Our exploratory study has demonstrated the association between p75(NTR) and SSRI response for the first time, which may assist in individualized therapy for MDD patients in the future.
    关键词: Genetics & Heredity;Psychiatry
    日期: 2008-07-05
    關聯: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2008 Jul;147B(5):594-599.
    Link to: http://dx.doi.org/10.1002/ajmg.b.30646
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1552-4841&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257447000008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=46949110138
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