國家衛生研究院 NHRI:Item 3990099045/3120

NHRI > National Institute of Environmental Health Sciences > Ying-Chin Ko(2003-2009) > Periodical Articles > Item 3990099045/3120

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3120

Title:	Relationship between insulin sensitivity and exposure to dioxins and polychlorinated biphenyls in pregnant women
Authors:	Chen, JW;Wang, SL;Liao, PC;Chen, HY;Ko, YC;Lee, CC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	The aim of this study was to examine the relationship between insulin sensitivity and polychlorinated biphenyls (PCBs) exposure in non-diabetic pregnant women. Forty gravidas, 21-39 years of age and residing within the study area, were recruited. Seventeen 2,3,7,8-substituted dichloro-p-dioxin, dibenzofurans and 12 PCBs were measured using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Serum insulin and glucose were also measured. Insulin sensitivity and the quantitative insulin sensitivity check index (QUICKI) were calculated based on fasting glucose and insulin levels. Three specific congeners of PCBs (123, 126, and 169) were significantly associated with insulin activity (r = -0.34 similar to-0.36, p < 0.05). Statistical analyses revealed that insulin sensitivity was significantly associated with age- and pre-pregnancy body mass indices (BMI)-adjusted for decreasing toxic equivalents (TEQ) of PCBs (p = 0.02 for age- and BMI-adjusted). We also performed an insulin correlation for total TEQ and the TEQ of PCBs, and determined that insulin sensitivity was predicted by the TEQ of PCBs by a regression coefficient of -0.189 after adjustment for age and pre-pregnancy BMI. These findings suggest that PCBs may be associated with decreasing insulin sensitivity in non-diabetic pregnant women; however, the mechanism remains to be ascertained.
Keywords:	Environmental Sciences;Public, Environmental & Occupational Health
Date:	2008-06
Relation:	Environmental Research. 2008 Jun;107(2):245-253.
Link to:	http://dx.doi.org/10.1016/j.envres.2008.01.004
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0013-9351&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000256331200013
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=43049172272
Appears in Collections:	[Ying-Chin Ko(2003-2009)] Periodical Articles [Shu-Li Wang] Periodical Articles

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