國家衛生研究院 NHRI:Item 3990099045/3119
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3119


    Title: CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Authors: Lee, KM;Kang, D;Clapper, ML;Ingelman-Sundberg, M;Ono-Kihara, M;Kiyohara, C;Min, S;Lan, Q;Le Marchand, L;Lin, PP;Lung, ML;Pinarbasi, H;Pisani, P;Srivatanakul, P;Seow, A;Sugimura, H;Tokudome, S;Yokota, J;Taioli, E
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: evaluate the roles of CYP1A1 polymorphisms [Ile (462)Val and (TC)-C-6235 (MspI)] and deletion of GSTM1 and and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (95% CD using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 C-6235 variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P-trend = 0.003). In haplotype analysis, (462)Val-T-6235 and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk (OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer risk as pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with IT genotype (P-interaction = 0.001) and with the GSTM1-null genotype compared with the present type (Pinteraction 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer risk in Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking.
    Keywords: Oncology;Public, Environmental & Occupational Health
    Date: 2008-05
    Relation: Cancer Epidemiology Biomarkers and Prevention. 2008 May;17(5):1120-1126.
    Link to: http://dx.doi.org/10.1158/1055-9965.EPI-07-2786
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1055-9965&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000256012800016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52649148138
    Appears in Collections:[Pinpin Lin] Periodical Articles

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