國家衛生研究院 NHRI:Item 3990099045/3116
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3116


    题名: Hypoxia-inducible factor-1 alpha regulates matrix metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells
    其它题名: Hypoxia-inducible factor-1α regulates matrix metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells
    作者: Lin, JL;Wang, MJ;Lee, D;Liang, CC;Lin, S
    贡献者: Institute of Cellular and Systems Medicine
    摘要: We examined the mRNA levels of hypoxia- inducible factor- 1a ( HIF- 1a) in bone marrow mesenchymal stem cells ( bmMSCs) of eight osteoarthritis patients. BmMSC- 1, expressing higher HIF- 1a mRNA and protein than bmMSC- 5, elicited higher matrix metalloproteinase- 1 ( MMP1) activity and stronger invasive capacity. In vitro invasion assays and quantitative PCR analyses showed that targeted inhibition of HIF- 1a in bmMSC- 1 decreased its invasion and expressions of MMP1 and MMP3, whereas overexpression of HIF- 1a in bmMSC- 5 increased its invasion and expressions of MMP1 and MMP3. Therefore, HIF- 1a can regulate MMP1 and MMP3 expressions in human bmMSCs, which might suggest a pathophysiological role of bmMSC expressing high HIF- 1a in bone diseases.
    关键词: Biochemistry & Molecular Biology;Biophysics;Cell Biology
    日期: 2008-07-23
    關聯: FEBS Letters. 2008 Jul;582(17):2615-2619.
    Link to: http://dx.doi.org/10.1016/j.febslet.2008.06.033
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-5793&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000258112000025
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=46949089391
    显示于类别:[林聖光(2004-2017)] 期刊論文
    [梁春金(2004-2009)] 期刊論文

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