國家衛生研究院 NHRI:Item 3990099045/3114
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    題名: High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression
    作者: Takamiya, R;Baron, RM;Yet, SF;Layne, MD;Perrella, MA
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Nitric oxide synthase (NOS)2, an inducible enzyme that produces NO during inflammation, is transcriptionally regulated. Our goal was to determine whether high mobility group (HMG)A1 contributes to human (h)NOS2 gene regulation. Using a small molecule inhibitor of RMGA1 binding to DNA, or a dominant-negative form of HMGA1, we blunted the induction of hNOS2 by pro-inflammatory stimuli. Binding of HMGA1 in the region -3506 to -3375 of the hNOS2 promoter, a region not previously. known to be involved in hNOS2 regulation, contributed to the induction of hNOS2 promoter in conjunction with upstream enhancer regions. We demonstrate a previously unknown role for HMGA1 in the regulation of hNOS2. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
    關鍵詞: Biochemistry & Molecular Biology;Biophysics;Cell Biology
    日期: 2008-03-05
    關聯: FEBS Letters. 2008 Mar;582(5):810-814.
    Link to: http://dx.doi.org/10.1016/j.febslet.2008.02.008
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-5793&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257670100045
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=39749176998
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