國家衛生研究院 NHRI:Item 3990099045/3099
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    题名: Critical role of p53 in histone deacetylase inhibitor-induced Epstein-Barr virus Zta expression
    作者: Chang, SS;Lo, YC;Chua, HH;Chiu, HY;Tsai, SC;Chen, JY;Lo, KW;Tsai, CH
    贡献者: National Institute of Cancer Research
    摘要: The tumor suppressor gene p53 plays a central role in the maintenance of normal cell growth and genetic integrity, while its impact on the Epstein-Barr virus (EBV) life cycle remains elusive. We found that p53 is important for histone deacetylase inhibitor-induced EBV lytic gene expression in nasopharyngeal carcinoma cells. Restoration of p53 in p53-null, EBV-infected H1299 cells augments the potential for viral lytic cycle initiation. Evidence from reporter assays demonstrated that p53 contributes to the expression of the immediate-early viral Zta gene. Further analysis indicated that the DNA-binding ability of p53 and phosphorylation of Ser392 may be critical. This study provides the first evidence that p53 is involved in the regulation of EBV lytic cycle initiation.
    关键词: Virology
    日期: 2008-08
    關聯: Journal of Virology. 2008 Aug;82(15):7745-7751.
    Link to: http://dx.doi.org/10.1128/JVI.02717-07
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-538X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257770500050
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47749134215
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