國家衛生研究院 NHRI:Item 3990099045/3080
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    题名: Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads
    作者: Van der Veken, P;De Meester, I;Dubois, V;Soroka, A;Van Goethem, S;Maes, MB;Brandt, I;Lambeir, AM;Chen, X;Haemers, A;Scharpe, S;Augustyns, K
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Dipeptide derivatives bearing various P2 residues and pyrrolidine derivatives as P1 mimics were evaluated in order to identify lead structures for the development of DPP8 and DPP9 inhibitors. Structure activity-relationship data obtained in this way led to the preparation of a series of alpha-aminoacyl ((2S, 4S)-4-azido-2-cyanopyrrolidines). These compounds were shown to be nanomolar DPP8/9 inhibitors with modest overall selectivity toward DPP IV and DPP II.
    关键词: Chemistry, Medicinal;Chemistry, Organic
    日期: 2008-07-15
    關聯: Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4154-4158.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2008.05.080
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257640400074
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47149104034
    显示于类别:[陳新(2002-2015)] 期刊論文

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