國家衛生研究院 NHRI:Item 3990099045/3071
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3071


    Title: Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases
    Authors: Kuo, CJ;Guo, RT;Lu, IL;Liu, HG;Wu, SY;Ko, TP;Wang, AHJ;Liang, PH
    Contributors: Division of Biotechnology and Pharmaceutical Research
    Abstract: Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In this study, we solved the crystal structure of H. pylori UPPS and performed virtual screening of inhibitors from a library of 58,635 compounds. Two hits were found to exhibit differential activities against Helicobacter Pylori and Escherichia coli UPPS, giving the possibility of developing antibiotics specially targeting pathogenic H. pylori without killing the intestinal E. coli.
    Keywords: Biotechnology & Applied Microbiology;Medicine, Research & Experimental
    Date: 2008
    Relation: Journal of Biomedicine and Biotechnology. 2008; 2008:Article number 841312.
    Link to: http://dx.doi.org/10.1155/2008/841312
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000255761300001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=42949132874
    Appears in Collections:[Su-Ying Wu] Periodical Articles

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