國家衛生研究院 NHRI:Item 3990099045/3029
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 853533      在线人数 : 1004
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3029


    题名: Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis
    作者: Huang, TS;Shu, CH;Yang, WK;WhangPeng, J
    贡献者: National Institute of Cancer Research
    摘要: CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G(2). Abnormal activation of cyclin B-associated CDC 2 kinase has been in;plicated in apoptosis induced by cancer chemotherapeutic agents such as paclitaxel (Taxol) and etoposide (VP-16), In this study, we found that the CDC 2 kinase could be transiently activated when nasopharyngeal carcinoma NPC-TW01 cells were treated for 3 h with a new anticancer agent, GL331, GL331 treatment also induced a concomitant increase in CDC 25A phosphatase activity and a reduced level of Tyr-15-phosphorylated CDC 2 in NPC-TW01 cells, Furthermore, subsequent apoptotic DNA fragmentation induced by GL331 could be interrupted by treatment of the cells with the cyclin B1-specific antisense oligonucleotides, suggesting that abnormal activation of cyclin B1-associated CDC 2 kinase and CDC 25A phosphatase was involved in GL331-induced apoptosis, Raf-1 has been shown to associate with CDC 25A and, thus, to stimulate its phosphatase activity, Our results revealed that GL331 could facilitate the association of CDC 25A with Raf-1, resulting in the cascade of CD0C 25A phosphatase activation and CDC 2 kinase activation, as well as related signaling pathways, and ultimately causing apoptosis in cancer cells.
    关键词: Oncology
    日期: 1997-07-15
    關聯: Cancer Research. 1997 Jul;57(14):2974-2978.
    Link to: http://cancerres.aacrjournals.org/cgi/content/abstract/57/14/2974
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:A1997XL16200032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030834333
    显示于类别:[彭汪嘉康(1996-2007)] 期刊論文
    [楊文光(1996-1999)] 期刊論文
    [黃智興] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    A1997XL16200032.pdf1049KbAdobe PDF830检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈