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http://ir.nhri.org.tw/handle/3990099045/3007
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| Title: | Additive effect of interleukin-12 and interleukin-18 on the T-helper cell pathway of malignant pleural effusion |
| Authors: | Yao, NS;Chen, YM;Perng, RP;Whang-Peng, J |
| Contributors: | National Institute of Cancer Research |
| Abstract: | Interleukin-18 (IL-18) is a novel cytokine with interferon-gamma (IFN-gamma)-inducing activity, thus favoring the T-helper type 1 (Th-1) pathway. The present study attempts to define the role of IL-18 on the functions of lymphocytes isolated from malignant pleural effusions (EAL, effusion-associated lymphocytes). EAL from 10 patients with malignant pleural effusion were incubated with IL-2, IL-12, or IL-18 with/without a alphaCD3 antibody. ELISA, proliferation, and cytotoxicity assays were performed. IL-18 alone was found to have no significant effect on EAL in terms of cytokine production, lymphocyte proliferation, or cytotoxicity against tumor targets. IL-18 also had no significant additive or synergistic effect on IL-2, IL-12, or alphaCD3 co-cultured EAL. However, when IL-18 was used with IL-12, the highest IFN-gamma/IL-10 ratio was derived, suggesting that these two cytokines had an additive effect in leading EAL from the Th-2 to the Th-1 pathway. Furthermore, 1 of 5 patients' EAL had its strongest cytolytic activity against an autologous tumor when the EAL was cultured with IL-2 plus IL-18, as compared with the other 4 patients whose EAL cytolytic activity against autologous tumor was highest when using IL-2 plus alphaCD3. These findings suggest that IL-18 alone did not have a significant effect on EAL, and that IL-18 did not enhance alphaCD3's activity on EAL. However, its additive effect with IL-12 in the Th-1 pathway and with IL-2 in its cytolytic activity against an autologous tumor deserve further studies. |
| Keywords: | Respiratory System |
| Date: | 2002-02 |
| Relation: | Lung. 2002 Feb;180(1):15-24. |
| Link to: | http://dx.doi.org/10.1007/s004080000077 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0341-2040&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000176211900002 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036901999 |
| Appears in Collections: | [彭汪嘉康(1996-2007)] 期刊論文
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| 000176211900002.pdf | | 101Kb | Adobe PDF | 272 | View/Open |
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