國家衛生研究院 NHRI:Item 3990099045/3002

NHRI > National Institute of Cancer Research > Jacqueline Whang-Peng(1996-2007) > Periodical Articles > Item 3990099045/3002

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Title:	Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system
Authors:	Lin, CT;Lyu, YL;Xia, H;Lin, WH;Whang-Peng, J
Contributors:	National Institute of Cancer Research
Abstract:	Mismatch repair (MMR)-deficient cells are shown to produce >15-fold more methotrexate-resistant colonies than MMR normal cells. The increased resistance to methotrexate is primarily due to gene amplification since all the resistant clones contain double-minute chromosomes and increased copy numbers of the DHFR gene. In addition, integration of linearized or retroviral DNAs into chromosomes is also significantly elevated in MMR-deficient cells. These results suggest that in addition to microsatellite instability and homeologous recombination, MMR is also involved in suppression of other genome instabilities such as gene amplification and chromosomal DNA integration.
Keywords:	Biochemistry & Molecular Biology
Date:	2001-08-15
Relation:	Nucleic Acids Research. 2001 Aug;29(16):3304-3310.
Link to:	http://dx.doi.org/10.1093/nar/29.16.3304
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0305-1048&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000170623700003
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035880770
Appears in Collections:	[Jacqueline Whang-Peng(1996-2007)] Periodical Articles [Ching-Tai Lin(1999-2007)] Periodical Articles

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