國家衛生研究院 NHRI:Item 3990099045/2984

NHRI > National Institute of Cancer Research > Jacqueline Whang-Peng(1996-2007) > Periodical Articles > Item 3990099045/2984

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2984

Title:	Renal cell carcinoma with t(X;17)(p11.2;q25) in a 6-year-old Taiwanese boy
Authors:	Chen, CK;Hsueh, C;Lai, JY;Hung, IJ;Whang-Peng, J;Wang, WP;Lai, HY;Chen, JR
Contributors:	National Institute of Cancer Research
Abstract:	Pediatric renal cell carcinoma (RCC) associated with ASPL-TFE3 gene fusion resulting from balanced translocation, t(X;17)(p11.2;q25), is a distinctive tumor entity. It is uncommon, and most reported cases have exclusively come from Western societies. We report a case of t(X;17)(p11.2;q25) RCC in a 6-year-old Taiwanese boy. The patient presented with dysuria and intermittent hematuria for 1 year. Nonenhanced CT showed a well-defined homogeneous hyperdensity lesion in the upper pole of the left kidney. This patient refused to receive immediate surgical procedures but had routine follow-ups. After a 9-month follow-up, the patient underwent total nephrectomy with a favorable outcome. Final diagnosis is established based on the characteristic microscopic features, strong nuclear TFE-3 immunoreactivity, and the presence of type 1 TFE3-ASPL fusion gene detected by reverse transcriptase-polymerase chain reactions. No adjuvant therapy is given, and the patient is alive without evidence of disease for 1 year and 6 months.
Keywords:	Pathology
Date:	2007-02
Relation:	Virchows Archiv. 2007 Feb;450(2):215-219.
Link to:	http://dx.doi.org/10.1007/s00428-006-0337-8
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0945-6317&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000244322700011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33847162078
Appears in Collections:	[Jacqueline Whang-Peng(1996-2007)] Periodical Articles [Jim-Ray Chen(2003-2007)] Periodical Articles

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