國家衛生研究院 NHRI:Item 3990099045/2983

NHRI > National Institute of Cancer Research > Jacqueline Whang-Peng(1996-2007) > Conference Papers/Meeting Abstract > Item 3990099045/2983

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Title:	Internal radiotherapy and dosimetric study for In-111/Lu-177-pegylated liposomes conjugates in tumor-bearing mice
Authors:	Wang, HE;Yu, HM;Lu, YC;Heish, NN;Tseng, YL;Huang, KL;Chuang, KT;Chen, CH;Hwang, JJ;Lin, WJ;Wang, SJ;Ting, G;Whang-Peng, J;Deng, WP
Contributors:	National Institute of Cancer Research
Abstract:	In vivo characterization and dosimetric analysis has been performed to evaluate the potential of pegylated liposomes as carriers of radionuclides in tumor internal radiotherapy. Methods: The DTPA/PEG-liposomes were synthesized with a medium size of 110 nm, conjugated with In-111/Lu-177-(oxine)(3) to afford In-111/Lu-177-liposome. The stability of In-111/Lu-177-liposome in serum was investigated. The biodistribution, scintigraphic imaging and pharmacokinetics of In-111/Lu-177-liposomes after intravenous(i.v.) injection into C-26 tumor-bearing BALB/cByJ mice were studied. Radiation dose was estimated by MIRD-III program. Results: The incorporation efficiency of In-111/Lu-177 into liposomes was 95%. After incubation at 37 degrees C for 72h in serum, more than 83% of radioactivity was still retained in the intact In-111/Lu-177-liposomes. The biodistribution of In-111-liposomes showed that the radioactivity in the blood decreased from 23.14 +/- 8.16%ID/g at 1 h to 0.02 +/- 0.00% ID/g at 72h post-injection (p.i.), while reaching its maximum accumulation in tumors at 48 h p.i., with half-life in blood of 10.2 h. The results were supported by that of Lu-177-liposomes. Scintigraphic imaging with In-111-liposomes showed unambiguous tumor images at 48 It p.i. Dose estimation showed that the absorbed dose in tumor from Lu-177-fposornes was 5.74 x 10(-5) Gy/MBq. Conclusions: This study provides an in vivo characterization and dosimetric evaluation for the use of liposome systems as carriers in targeted radionuclide therapy. The results suggest that adequate tumor targeting as well as dose delivered to tumors could be achieved by the use of radionuclide targeted liposomes.
Keywords:	Instruments & Instrumentation;Nuclear Science & Technology;Physics, Particles & Fields;Spectroscopy
Date:	2006-12-20
Relation:	Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2006 Dec;569(2):533-537.
Link to:	http://dx.doi.org/10.1016/j.nima.2006.08.124
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-9002&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000243241300084
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751420619
Appears in Collections:	[Jacqueline Whang-Peng(1996-2007)] Conference Papers/Meeting Abstract

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