國家衛生研究院 NHRI:Item 3990099045/2982
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    题名: Therapeutic efficacy evaluation of 111in-VNB-liposome on human colorectal adenocarcinoma HT-29/luc mouse xenografts
    其它题名: Therapeutic efficacy evaluation of (111)in-VNB-liposome on human colorectal adenocarcinoma HT-29/luc mouse xenografts
    作者: Lee, WC;Hwang, JJ;Tseng, YL;Wang, HE;Chang, YF;Lu, YC;Ting, G;Whang-Peng, J;Wang, SJ
    贡献者: National Institute of Cancer Research
    摘要: The purpose of this study is to evaluate the therapeutic efficacy of the liposome encaged with vinorelbine (VNB) and In-111-oxine on human colorectal adenocarcinoma (HT-29) using HT-29/luc mouse xenografts. HT-29 cells stably transfected with plasmid vectors containing luciferase gene (luc) were transplanted subcutaneously into the male NOD/SCD mice. Biodistribution of the drug was performed when tumor size reached 500-600 mm(3). The uptakes of In-111-VNB-liposome in tumor and normal tissues/organs at various time points postinjection were assayed. Multimodalities, including gamma scintigraphy, bioluminescence imaging (BLI) and whole-body autoradiography (WBAR), were applied for evaluating the therapeutic efficacy when tumor size was about 100 mm(3). The tumor/blood ratios of In-111-VNB-liposome were 0.044, 0.058, 2.690, 20.628 and 24.327, respectively, at 1, 4, 24, 48 and 72h postinjection. Gamma scinitigraphy showed that the tumor/muscle ratios were 2.04, 2.25 and 4.39, respectively, at 0, 5 and 10 mg/kg VNB. BLI showed that significant tumor control was achieved in the group of 10 mg/kg VNB (In-111-VNB-liposome). WBAR also confirmed this result. In this study, we have demonstrated a non-invasive imaging technique with a luciferase reporter gene and BLI for evaluation of tumor treatment efficacy in vivo. The SCID mice bearing HT-29/luc xenografts treated with In-111-VNB-liposome were shown with tumor reduction by this technique.
    关键词: Instruments & Instrumentation;Nuclear Science & Technology;Physics, Particles & Fields;Spectroscopy
    日期: 2006-12-20
    關聯: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2006 Dec;569(2):497-504.
    Link to: http://dx.doi.org/10.1016/j.nima.2006.08.135
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-9002&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000243241300076
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751430072
    显示于类别:[彭汪嘉康(1996-2007)] 會議論文/會議摘要

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