國家衛生研究院 NHRI:Item 3990099045/2960
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    题名: erb-b2 amplification by fluorescence in situ hybridization in breast cancer specimens read as 2+in immunohistochemical analysis
    作者: Lan, C;Liu, JM;Liu, TW;Hsu, DH;Liang, SC;Chen, JR;Whang-Peng, J
    贡献者: National Institute of Cancer Research
    摘要: We conducted this study to ascertain the prevalence of erb-b2 gene amplification in breast cancer specimens read as 2+ in immunohistochemical analysis. Slides from patients with metastatic or recurrent breast cancer were eligible for fluorescent in situ hybridization (FISH) study if they were read as 2+ immunohistochemically for erb-b2 by a certified pathologist. The PathVysion kit (Vysis, Downers Grove, IL) was used for FISH studies. Amplification of the erb-b2 gene was defined as an erb-b2/CEP17 (chromosome 17 centromere) ratio of 2 or more in 30 tumor cells counted. From May 2003 to June 2004, 221 slides were submitted from 24 hospitals around the island. Of 216 successful hybridizations, 96 (44.4%) were determined to be erb-b2 amplified. In addition, the topoisomerase II alpha gene was coamplified in 11 (21%) of 53 and deleted in 8 (15%) of 53 erb-b2 amplified cases. The erb-b2 gene amplification rate was very high in cases determined to be 2+ by immunohistochemical analysis; therefore, determination of erb-b2 status by FISH in cases scored 2+ immunohistochemically is strongly recommended.
    关键词: Pathology
    日期: 2005-07
    關聯: American Journal of Clinical Pathology. 2005 Jul;124(1):97-102.
    Link to: http://dx.doi.org/10.1309/R2X4KK22QCL7PLME
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9173&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000229976700013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=21744433507
    显示于类别:[彭汪嘉康(1996-2007)] 期刊論文
    [劉敏(1996-2007)] 期刊論文
    [劉滄梧] 期刊論文
    [陳俊叡(2003-2007)] 期刊論文

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