國家衛生研究院 NHRI:Item 3990099045/2947

NHRI > National Institute of Cancer Research > Jacqueline Whang-Peng(1996-2007) > Conference Papers/Meeting Abstract > Item 3990099045/2947

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2947

Title:	Randomized clinical trial of morbidity after D1 and D3 surgery for gastric cancer
Authors:	Wu, CW;Hsiung, CA;Lo, SS;Hsieh, MC;Shia, LT;Whang-Peng, J
Contributors:	National Institute of Cancer Research;Division of Biostatistics and Bioinformatics
Abstract:	Background: A randomized comparison of D1 (level 1 lymphadenectomy) and D3 (levels 1, 2 and 3 lymphadenectomy) dissection was performed to evaluate morbidity and effects on survival from gastric cancer. Methods: A total of 221 patients were studied after resection for gastric cancer, 110 after D1 surgery and 111 after D3 surgery. Results: The morbidity rate was higher after D3 than after D1 resection (17.1 (95 per cent confidence interval (c.i.) 10.1 to 24.1) versus 7.3 (95 per cent c.i. 2.4 to 12.2) per cent respectively; P = 0.012). The difference was largely related to abdominal abscess (8.1 per cent after D3 versus none after D1 resection; P = 0.003). The D3 group had an anastomotic leak rate of 4.5 per cent whereas there was no leakage in the D1 group (P = 0.060). All anastomotic leaks were minor and were managed non-operatively with nutritional support. Patients who had D3 resection had longer operating times, greater blood loss and postoperative drain outputs, and more patients needed blood transfusion. There was no death in either group. The hospital stay was longer after D3 than D1 surgery (mean(s.d.) 19.6(13.9) (range 10-98) versus 15.0(4.0) (range 10-30) days; P = 0.001). Conclusion: Extended lymphadenectomy for gastric cancer is associated with more complications than limited lymphadectomy but this does not lead to significant mortality.
Keywords:	Surgery
Date:	2004-03
Relation:	British Journal of Surgery. 2004 Mar;91(3):283-287.
Link to:	http://dx.doi.org/10.1002/bjs.4433
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-1323&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000220667000006
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1642371459
Appears in Collections:	[Jacqueline Whang-Peng(1996-2007)] Conference Papers/Meeting Abstract [Chao A. Hsiung] Conference Papers/Meeting Abstract

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