國家衛生研究院 NHRI:Item 3990099045/2928

NHRI > National Institute of Cancer Research > Ming Jacqueline Liu(1996-2007) > Periodical Articles > Item 3990099045/2928

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2928

Title:	Fulminant hepatitis is significantly increased in hepatitis B carriers after allogeneic bone marrow transplantation
Authors:	Chen, PM;Chiou, TJ;Fan, FS;Liu, JM;Hsieh, RK;Yen, CC;Wang, WS;Liu, JH
Contributors:	National Institute of Cancer Research
Abstract:	Background. Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. Methods. Forty three hepatitis B virus carriers received high-dose chemotherapy and BMT, 32 patients received an allogeneic graft, and 11 patients autologous marrow. Acute graft-versus-host disease prophylaxis consisted of methotrexate on day 1, 3, 6, and 11 and cyclosporine for B months. Results. After a median follow-up period of 68 months (range: 1-11.5 years), 26 (81.3%) allogeneic BMT patients developed impaired liver function (LF), 5 progressed to FH on day 93, 169, 170, 180, and 468, respectively, and died after an average of 13.8 days (range: 1-45 days). Whereas only 4 (36.4%) autologous BMT patients developed impaired LF, and none FH, Impaired LF (P=0.026, chi-square), and FH (odds ratio=12.86, P=0.009 for coefficient) were significantly related to an allogeneic marrow graft, and the timing of liver function impairment coincided with cyclosporine withdrawal. Hepatitis B surface antigen (HbsAg) disappeared from the serum in 4/14(28.6%) patients receiving a marrow graft from an HbsAg+ donor, HbsAg was not detected in the serum after BMT in 2/11 (18.2%) autologous BMT patients. Conclusions. Hepatitis B virus carriers receiving a marrow graft from an HbsAg+ donor have a significantly increased risk of FH.
Keywords:	Immunology;Surgery;Transplantation
Date:	1999-06-15
Relation:	Transplantation. 1999 Jun;67(11):1425-1433.
Link to:	http://dx.doi.org/10.1097/00007890-199906150-00006
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0041-1337&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000080949500006
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033564450
Appears in Collections:	[Ming Jacqueline Liu(1996-2007)] Periodical Articles

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