國家衛生研究院 NHRI:Item 3990099045/2912
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2912


    Title: Microsatellite instability in sporadic-colon-cancer patients with and without liver metastases
    Authors: Chen, WS;Chen, JY;Liu, JM;Lin, WC;King, KL;Whang-Peng, J;Yang, WK
    Contributors: National Institute of Cancer Research
    Abstract: Microsatellite instability (MSI) is intrinsic to most colorectal carcinomas (CRC) from patients with hereditary nonpolyposis colorectal cancer (HNPCC), reflecting germline mutations in the mismatch-repair (MMR) genes. Its occurrence and chronological sequence of development in sporadic CRC appears less well defined. To explore the time sequence in acquisition of MSI, and the role it plays during tumor progression in sporadic CRC, we compared the incidence of MSI in tissue samples from 40 Dukes'-B and 30 Dukes'-D CRC patients with liver metastases, at 4 different microsatellite loci, representing sites on the APC, DCC and p53 genes respectively as well as the D2S123 site. Among the 30 patients with hepatic metastases, MSI was found in 9 (30%) of the primary, and 13 (43.3%) of the metastatic tumors. In comparison, among the 40 Dukes'-B CRC, MSI was found in only 8 cases (20%). CRC with MSI were more frequently located in the right colon, less frequently on the left side, and seldom in the rectum. Tumor ploidy analysis shows that 46.2% of Dukes'-D primary tumors with MSI are diploid (chi(2) = 4.46, p = 0.035). With a mean follow-up time of 4.2 years for the Dukes'-B CRC, there were no recurrences in the 8 patients with MSI, whilst 6 (18.8%) relapses occurred amongst the 32 patients without MSI, average time to recurrence being 15 months. In Dukes'-D CRC, mean survival time for patients with MSI was 37 months (95% CI, 24 to 51 months), for those without MSI 26 months (95% CI, 18 to 35 months), although this was not statistically significant. Our data suggest that tumor progression may involve increased genetic instability.
    Keywords: Oncology
    Date: 1997-08-22
    Relation: International Journal of Cancer. 1997 Aug;74(4):470-474.
    Link to: http://www3.interscience.wiley.com/journal/42329/abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:A1997XU12400020
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030863878
    Appears in Collections:[Wen-Kuang Yang(1996-1999)] Periodical Articles
    [Ming Jacqueline Liu(1996-2007)] Periodical Articles
    [Jacqueline Whang-Peng(1996-2007)] Periodical Articles

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