國家衛生研究院 NHRI:Item 3990099045/2878
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    題名: Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A
    作者: Yu, CTR;Wu, JC;Liao, MC;Hsu, SL;Huang, CYF
    貢獻者: National Institute of Cancer Research
    摘要: The c-Fos has been implicated in the regulation of gene expression under a variety of stimuli. It is known that c-Fos undergoes protein phosphorylation, which may subsequently modulate diverse functions in cells. However, less is known about the role and phosphorylation status of c-Fos during mitosis. Here, we showed that c-Fos exhibited an electrophoretic mobility up-shift as detected by SDS-PAGE during mitosis, which is an indication of protein phosphorylation. Aurora-A, but not Aurora-B or -C, serves as one of the kinases catalyzing the mitotic phosphorylation of c-Fos. The mobility up-shift was partially abolished by introducing siRNA or a catalytically inactive form of Aurora-A. Moreover, ectopic expression of the wild type, but not the catalytically inactive form of Aurora-A resulted in the alteration of c-Fos complex formation, suggesting Aurora-A is engaged in the regulation of c-Fos protein-protein interaction. These findings imply that c-Fos may undergo cell cycle dependent phosphorylation, in which some kinases including Aurora-A play a role in catalyzing the post translational modification of c-Fos.
    關鍵詞: Medicine, Research & Experimental
    日期: 2008-01
    關聯: Journal of Biomedical Science. 2008 Jan;15(1):79-87.
    Link to: http://dx.doi.org/10.1007/s11373-007-9209-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000251371100008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36749087054
    顯示於類別:[黃奇英(2005-2007)] 期刊論文

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