國家衛生研究院 NHRI:Item 3990099045/2875
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    題名: Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer
    作者: Chen, KY;Lee, YCG;Lai, JM;Chang, YL;Lee, YC;Yu, CJ;Huang, CYF;Yang, PC
    貢獻者: National Institute of Cancer Research
    摘要: The explosion of microarray studies has promised to shed light on the identification of disease markers. To find novel prognostic factors, we used the expression profile of a poor prognostic factor of lung cancer, survivin (BIRC5), as a template to search for and compare transcriptome expression profiles in a lung adenocarcinoma. microarray dataset. Trophinin (TRO) was identified as one of the best-correlated genes. The trophinin expression in lung cancer specimens was examined by immunohistochemical staining. The role of trophinin in cancer metastasis was further investigated by approaches of overexpression and knock down with small interfering RNA (siRNA). For stage I lung adenocarcinoma, the patients without trophinin expression had a better overall and disease-free survival. Overexpression. of trophinin increases cell invasion ability and knock down with siRNA inhibits cell invasion. Through a combination of data mining and biochemical assays, we identified trophinin, which could enhance cell invasion, as a novel prognostic factor for early stage lung cancer. (c) 2006 Elsevier Ltd. All rights reserved.
    關鍵詞: Oncology
    日期: 2007-03
    關聯: European Journal of Cancer. 2007 Mar;43(4):782-790.
    Link to: http://dx.doi.org/10.1016/j.ejca.2006.09.029
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000245322200026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33947674288
    顯示於類別:[黃奇英(2005-2007)] 期刊論文

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