國家衛生研究院 NHRI:Item 3990099045/2868
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    题名: Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland
    作者: Friborg, J;Jarrett, RF;Liu, MY;Falk, KI;Koch, A;Olsen, OR;Duncan, P;Wohlfarht, J;Chen, JY;Melbye, M
    贡献者: National Institute of Cancer Research
    摘要: Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma-high-incidence area, we compared EBV serology and viral load in high-risk nasopharyngeal carcinoma family members (N=20) and controls without nasopharyngeal carcinoma-affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti-VCA IgA-negative, anti-VCA IgA-positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) (P<0.01). The very high prevalence of anti-VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits.
    关键词: Virology
    日期: 2007-12
    關聯: Journal of Medical Virology. 2007 Dec;79(12):1877-1881.
    Link to: http://dx.doi.org/10.1002/jmv.21014
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-6615&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000250319100013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=35548982078
    显示于类别:[陳振陽] 期刊論文
    [劉玫英(2004-2006)] 期刊論文

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