國家衛生研究院 NHRI:Item 3990099045/2860
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    题名: Reactivation of Epstein-Barr virus can be triggered by an Rta protein mutated at the nuclear localization signal
    作者: Hsu, TY;Chang, Y;Wang, PW;Liu, MY;Chen, MR;Chen, JY;Tsai, CH
    贡献者: National Institute of Cancer Research
    摘要: Rta, an immediate-early protein of Epstein-Barr virus (EBV), is a transcriptional activator that induces lytic gene expression and triggers virus reactivation. Being located predominantly in, the nucleus, Rta can exert its transactivation function through either direct DNA binding of certain indirect mechanisms mediated by cellular signalling and other transcriptional factors. This study examined whether the subcellular localization of Rta was critical for the induction oil target genes. First (KRKK413)-K-410 was identified as a nuclear localization signal (NLS) of Ria. An Ria mutant with the NLS converted to (410)AAAA(413) showed cytoplasmic localization and failed to activate the promoter of BGLF5. Interestingly, ectopic expression of the Rta mutant still disrupted EBV latency in an epithelial cell line. Reporter gene assays revealed that the NLS-mutated Ria retained the ability to activate two lytic promoters, Zp and Rp, at a considerable level. Thus,, the cytoplasmic Rta mutant could induce expression of endogenous Zta and Ria. triggering reactivation of EBV.
    关键词: Biotechnology & Applied Microbiology;Virology
    日期: 2005-02
    關聯: Journal of General Virology. 2005 Feb;86(2):317-322.
    Link to: http://dx.doi.org/10.1099/vir.0.80556-0
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1317&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000226738500008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=13644269953
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