國家衛生研究院 NHRI:Item 3990099045/2839
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2839


    Title: Non-surgical treatment for afferent loop syndrome in recurrent gastric cancer complicated by peritoneal carcinomatosis: percutaneous transhepatic duodenal drainage followed by 24-hour infusion of high-dose fluorouracil and leucovorin
    Authors: Lee, KD;Liu, TW;Wu, CW;Tiu, CM;Liu, JM;Chung, TR;Chang, JY;Whang-Peng, J;Chen, LT
    Contributors: National Institute of Cancer Research
    Abstract: Afferent loop syndrome (ALS) is a debilitating complication of recurrent gastric cancer. Surgical intervention is usually not feasible in the face of poor general performance, presence of advanced peritoneal carcinomatosis and limited survival of the patients. Non-surgical approaches include internal drainage by stenting at the stenotic or anastomotic site and external drainage via the percutaneous routes. Percutaneous transhepatic duodenal drainage (PTDD) has been shown to provide effective palliation for ALS, but long-term catheterization is usually inevitable. We hereby present two cases of recurrent gastric cancer whose ALS was successfully treated with PTDD followed by weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin (HDFL). PTDD rapidly ameliorated the incapacitating symptom,; of ALS, and the effective, low-toxicity chemotherapy subsequently led to tumor regression, restoration of bowel patency and removal of the drainage tube. At present, both patients have remained ALS-free and drainage-free for 16 and 17 months, respectively. Our results indicate that this non-surgical approach with PTDD followed by weekly HDFL could serve as a safe and effective treatment for ALS in recurrent gastric cancer complicated by peritoneal carcinomatosis.
    Keywords: Oncology
    Date: 2002-07
    Relation: Annals of Oncology. 2002 Jul;13(7):1151-1155.
    Link to: http://dx.doi.org/10.1093/annonc/mdf212
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0923-7534&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000177060300031
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035990850
    Appears in Collections:[Li-Tzong Chen] Periodical Articles
    [Ming Jacqueline Liu(1996-2007)] Periodical Articles
    [Tsang-Wu Liu] Periodical Articles
    [Jang-Yang Chang] Periodical Articles
    [Jacqueline Whang-Peng(1996-2007)] Periodical Articles
    [Kuan-Te Li(1997-2004)] Periodical Articles

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