國家衛生研究院 NHRI:Item 3990099045/2808
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2808


    Title: Oxaliplatin added to simplified bimonthly low-dose leucovorin and 5-FU for pretreated advanced colorectal cancer is effective and not affected by different previous 5-FU regimens
    Authors: Hsieh, RK;Chao, TY;Chen, WS;Yang, TS;Chen, LT;Chen, PM;Liu, JH
    Contributors: National Institute of Cancer Research
    Abstract: This phase II study examined bimonthly oxaliplatin (85 mg/m(2)) added to a continuous infusion of fluorouracil (3000 mg/m(2) for 46 It following a 400 mg/m(2) bolus), with leucovorin (LV) (150 mg/m2) administrated in a simplified way to patients with metastatic colorectal cancers (CRC) refractory or resistant to 5-fluorouracil (5-FU). Sixty patients were registered. Of the 52 evaluable patients, 3 (5.8%) achieved a complete response (CR) and 18 (34.6%) achieved a partial response (PR). The overall response rate (CR+PR) was 40.4% (95% confidence interval [CI]: 26.6%-54.2%) for evaluable patients and 35% (95% CI: 22.6%-47.4%) by intention to treat. The median progression-free survival (PFS) was 5.2 months, and the median survival was 14.2 months. No significant differences were seen in response rates and PFS of patient groups pretreated either with high-dose 5-FU/LV by continuous infusion or with intravenous 5-FU/LV by a weekly bolus. From the 421 cycles analyzed, dose-limiting toxicities included cumulative sensory neuropathy and leukopenia, accounting for 11.6% and 10.0%, National Cancer Institute-Common Toxicity Criteria grade 3/4 toxicities per patient, respectively. Two (3.3%) patients experienced hepatic encephatopathy related to high-dose 5-FU. With necessary caution, this regimen was effective for 5-FU-pretreated CRC, regardless of ethnic differences, and it had the advantage of LV being administrated at a low dose in a simplified way.
    Keywords: Oncology
    Date: 2004
    Relation: Cancer Investigation. 2004;22(2):171-179.
    Link to: http://dx.doi.org/10.1081/CNV-120030204
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0735-7907&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000221848500001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=2642586573
    Appears in Collections:[Li-Tzong Chen] Periodical Articles

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