國家衛生研究院 NHRI:Item 3990099045/2799
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/2799


    题名: 2-amino and 2 '-aminocombretastatin derivatives as potent antimitotic agents
    作者: Chang, JY;Yang, MF;Chang, CY;Chen, CM;Kuo, CC;Liou, JP
    贡献者: National Institute of Cancer Research
    摘要: A novel series of 2-amino and 2'-aminocombretastatin derivatives were synthesized and evaluated for antitumor activity. Several compounds had excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 11, 20, and 21 with IC50 values of 1.6, 1.7, and 1.8 mu M, respectively, exhibited more potent inhibition of tubulin polymerization than colchicine and approximately as active as combretastatin A-4. They also displayed antiproliferative activity with an IC50 values ranging from 11 to 44 nM in a variety of human cell lines from different organs. Structure activity relationship information suggests that the NH2 substituent at the 2-position of either ring A or ring B in combretastatin molecular skeleton may play an important role in the bioactivity of this series of compounds.
    关键词: Chemistry, Medicinal
    日期: 2006-10-19
    關聯: Journal of Medicinal Chemistry. 2006 Oct;49(21):6412-6415.
    Link to: http://dx.doi.org/10.1021/jm060616k
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241192400032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750134570
    显示于类别:[郭靜娟] 期刊論文
    [張俊彥] 期刊論文

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