國家衛生研究院 NHRI:Item 3990099045/2778
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    题名: Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-kappa B activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa
    作者: Lu, YS;Yeh, PY;Chuang, SE;Gao, M;Kuo, ML;Cheng, AL
    贡献者: National Institute of Cancer Research
    摘要: Glucocorticoids (GCs) are commonly co-administered with cisplatin in the treatment of patients with carcinomas to prevent drug-induced allergic reaction, nausea and vomiting. Although GC receptor (GR) is ubiquitous in carcinoma cells and has been linked to signal transduction pathways pertinent to cell growth and apoptosis, little is known regarding the possible effect of GC on the chemosensitivity of carcinomas. Our previous study demonstrated that dexamethasone (DEX) enhances the cytotoxicity to cisplatin in a GR-rich human cervical carcinoma cell line, SiHa. In this study, we found that this cisplatin cytotoxicity-enhancing effect of DEX correlated well with its effect on abrogating the cisplatin-induced activation of nuclear factor kappa B (NF-kappa B). RU486, a structural homologue of DEX, partially reversed this cytotoxicity-enhancing effect of DEX, a finding consistent with the well-known partial reversing effect of RU486 on DEX-induced NF-kappa B suppression. Furthermore, expression of a dominant-negative truncated I kappa B alpha gene in SiHa cells completely abolished the cisplatin cytotoxicity-enhancing effect of DEX. Our data suggest that the specific action of DEX on GR may enhance the cytotoxicity of cisplatin in selected GR-rich cancer cells by suppressing NF-kappa B activation.
    关键词: Endocrinology & Metabolism
    日期: 2006-02
    關聯: Journal of Endocrinology. 2006 Feb;188(2):311-319.
    Link to: http://dx.doi.org/10.1677/joe.1.06453
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-0795&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000235445100016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33244480810
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