國家衛生研究院 NHRI:Item 3990099045/2756
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    题名: Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8(+) T cells
    作者: Liu, KJ;Lu, LF;Cheng, HT;Hung, YM;Shiou, SR;Whang-Peng, J;Juang, SH
    贡献者: National Institute of Cancer Research
    摘要: To improve the efficacy of tumor cell-based and dendritic cell (DC)-based cancer vaccines, this study explored the potential of a new cancer vaccine strategy, that is, the use of CD40 ligand-transfected tumor (CD40L-tumor) cells to simultaneously deliver both tumor-derived antigens (Ag) and maturation stimuli to DCs. Materials from frozen/thawed or irradiated human tumor cells, with or without surface CD40L, were internalized efficiently by immature DCs after coincubation. However, during the internalization process, only coculturing with irradiated CD40L-tumor cells resulted in concurrent, optimal DC maturation and production of proinflammatory chemokines and pro-Th1 cytokines, such as IL-6, IL-8, IL-12, IFN-gamma, and TNF-alpha. These activated DCs were the most potent cells to support the growth of CD8(+), IFN-gamma-producing T cells, and to process tumor Ag for the generation of specific cytotoxic T cells in vitro. Animals vaccinated with irradiated CD40L-tumor cell-pulsed DCs were better protected against subsequent challenge of a weakly immunogenic tumor cell line than animals vaccinated with irradiated CD40L-tumor cells alone. Thus, our results strongly support the future clinical application of using DCs pulsed with irradiated CD40L-tumor cells as a cancer vaccine.
    关键词: Biotechnology & Applied Microbiology;Oncology;Genetics & Heredity;Medicine, Research & Experimental
    日期: 2004-02
    關聯: Cancer Gene Therapy. 2004 Feb;11(2):135-147.
    Link to: http://dx.doi.org/10.1038/sj.cgt.7700663
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-1903&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000188224300007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0942268831
    显示于类别:[莊聲宏(1997-2004)] 期刊論文
    [劉柯俊] 期刊論文
    [彭汪嘉康(1996-2007)] 期刊論文

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