國家衛生研究院 NHRI:Item 3990099045/2741
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/2741


    题名: Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents
    作者: Hsieh, HP;Liou, JP;Lin, YT;Mahindroo, N;Chang, JY;Yang, YN;Chern, SS;Tan, UK;Chang, CW;Chen, TW;Lin, CH;Chang, YY;Wang, CC
    贡献者: National Institute of Cancer Research;Division of Biotechnology and Pharmaceutical Research
    摘要: Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role. (C) 2002 Elsevier Science Ltd. All rights reserved.
    关键词: Chemistry, Medicinal;Chemistry, Organic
    日期: 2003-01-06
    關聯: Bioorganic and Medicinal Chemistry Letters. 2003 Jan;13(1):101-105.
    Link to: http://dx.doi.org/10.1016/S0960-894X(02)00850-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000180058000021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=10744225059
    显示于类别:[張俊彥] 期刊論文
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