國家衛生研究院 NHRI:Item 3990099045/2694
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2694


    Title: The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression
    Authors: Chiou, SH;Yang, YP;Lin, JC;Hsu, CH;Jhang, HC;Yang, YT;Lee, CH;Ho, LLT;Hsu, WM;Ku, HH;Chen, SJ;Chen, SSL;Chang, MDT;Wu, CW;Juan, LJ
    Contributors: National Institute of Cancer Research
    Abstract: Human CMV (HCMV) is a widespread human pathogen that causes blindness by inducing retinitis in AIDS patients. Previously, we showed that viral immediate early 2 (IE2) protein may allow HCMV to evade the immune control by killing the Fas receptor-positive T lymphocytes attracted to the infected retina with increased secretion of Fas ligand (FasL). In this study, we further demonstrate that the secreted FasL also kills uninfected Fas-rich bystander retinal cells and that IE2 simultaneously protects the infected cells from undergoing apoptotic death, in part, by activating the expression of cellular FLIP (c-FLIP), an antiapoptotic molecule that blocks the direct downstream executer caspase 8 of the FasL/Fas pathway. c-FLIP induction requires the N-terminal 98 residues of IE2 and the c-FLIP promoter region spanning nucleotides -978 to -696. In vivo association of IE2 to this region, IE2-specific c-FLIP activation, and decrease of FasL-up-regulated activities of caspases 8 and 3 were all demonstrated in HCMV-infected human retinal cells. Moreover, c-FLIP up-regulation by IE2 appeared to involve P13K and might also render cells resistant to TRAIL-mediated death. Finally, enhanced c-FLIP signals were immunohistochemically detected in FE-positive cells in the HCMV-infected lesions of the human retina. Taken together, these data demonstrate specific activation of c-FLIP by HCMV IE2 and indicate a novel role for c-FLIP in the pathogenesis of HCMV retinitis.
    Keywords: Immunology
    Date: 2006-11-01
    Relation: Journal of Immunology. 2006 Nov;177(9):6199-6206.
    Link to: http://www.jimmunol.org/cgi/content/abstract/177/9/6199
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1767&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241477400053
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750322789
    Appears in Collections:[Li-Jung Juan(2000-2006)] Periodical Articles
    [Cheng-Wen Wu(1996-2008)] Periodical Articles

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