國家衛生研究院 NHRI:Item 3990099045/2687
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2687


    Title: Binary/ternary combined effects of vitamin K-3 with other antitumor agents in nasopharyngeal carcinoma CG1 cells
    Authors: Liao, WC;Wu, FYH;Wu, CW
    Contributors: National Institute of Cancer Research
    Abstract: Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Taiwan. To improve the treatment of NPC, we have extensively searched for effective combination chemotherapies. Our previous studies indicated that vitamin K-3 (VK3) inhibits the growth of NPC CG1 cells in vitro. In this study, we further studied the binary/ternary combined effects of VK3 with other anticancer drugs against NPC cells. The antitumor effects of different VK3 combinations against CG1 cells were determined by using MTT assay, and the combined effects were evaluated by a taibologram, a modified isobolographic method being developed in our laboratory for the analyses of binary/ternary combinations of anticancer agents, Binary combinations of VK3 with doxorubicin (DOX), vinblastine (VBL), or 5-fluorouracil (5-FU) result in synergistic effects. For three-drug combinations, a remarkable synergy was found in the combination of VK3, VBL, and 5-FU. These in vitro results will provide useful information not only for further mechanistic studies and but also fur future clinical trials of VK3-based cancer chemotherapy of NPC.
    Keywords: Oncology
    Date: 2000-08
    Relation: International Journal of Oncology. 2000 Aug;17(2):323-328.
    Link to: http://www.ncbi.nlm.nih.gov/sites/entrez?myncbishare=nhrilib&Db=pubmed&Cmd=DetailsSearch&Term=10891542
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1019-6439&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000088208700016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034242787
    Appears in Collections:[Cheng-Wen Wu(1996-2008)] Periodical Articles

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