國家衛生研究院 NHRI:Item 3990099045/2680
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    题名: p53 amino acids 339-346 represent the minimal p53 repression domain
    作者: Hong, TM;Chen, JJW;Peck, K;Yang, PC;Wu, CW
    贡献者: National Institute of Cancer Research
    摘要: The p53 tumor suppressor protein functions as an activator and also as a repressor of gene transcription. Currently, the mechanism of transcriptional repression by p53 remains poorly understood. To help clarify this mechanism, we carried out studies designed to identify the minimal repression domain that inhibits p53 transcriptional activities. We found only eight amino acids (339-346) of the COOH-terminal domain (termed P53MRD) that possess activities of repression, The exact location of this minimal domain is on the EG-binding region, and it lacks the ability of tetramerization. P53MRD is able to repress the transcription of p53 while not affecting VP16. The mutants (amino acids M340P and F341D) of native p53 also lost transcriptional repression of the thymidine kinase chloramphenicol acetyltransferase promoter. These results suggest that this eight-amino acid element is required for the repression of p53.
    关键词: Biochemistry & Molecular Biology
    日期: 2001-01-12
    關聯: Journal of Biological Chemistry. 2001 Jan;276(2):1510-1515.
    Link to: http://dx.doi.org/10.1074/jbc.M008231200
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000166430900087
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035847023
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