國家衛生研究院 NHRI:Item 3990099045/2673
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2673


    Title: Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome
    Authors: Shieh, YS;Chang, LC;Chiu, KC;Wu, CW;Lee, HS
    Contributors: National Institute of Cancer Research
    Abstract: Background: Alteration of cadherin and catenin expression is associated with loss of differentiation, acquisition of an invasive phenotype, and poor prognosis in many types of cancers. The roles of cadherins and catenins in mucoepidermoid carcinoma (MEC) are not fully understood. Methods: Based on immunohistochemical studies, the expressions of E-, N-, and P-cadherins and alpha-, beta-, and gamma-catenins in MEC were investigated, and correlations with clinicopathologic parameters were evaluated. Results: These six molecules were strongly expressed in normal ductal epithelium but increased or decreased immunoreactivities of those proteins in MEC were frequently observed, especially for E-cadherin and alpha-catenin. The immunoactivity of beta-catenin showed significant correlation with grade (P=0.05) and stage (P<0.0001). beta-Catenin expressions are also correlated with gamma-catenin expression (P=0.006) according to cross-table analysis. Survival analysis indicated that stage, grade, and beta-catenin expressions had significant correlation with survival. Conclusion: Aberrant beta-catenin expression may play an important role in the histologic differentiation and tumor staging of MEC.
    Keywords: Dentistry, Oral Surgery & Medicine;Pathology
    Date: 2003-05
    Relation: Journal of Oral Pathology and Medicine. 2003 May;32(5):297-304.
    Link to: http://dx.doi.org/10.1034/j.1600-0714.2003.00144.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0904-2512&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000182190300008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037542514
    Appears in Collections:[Cheng-Wen Wu(1996-2008)] Periodical Articles

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