國家衛生研究院 NHRI:Item 3990099045/2665
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    題名: Aberrant expression of cell-cycle regulator cyclin DI in breast cancer is related to chromosomal genomic instability
    作者: Lung, JCY;Chu, JS;Yu, JC;Yue, CT;Lo, YL;Shen, CY;Wu, CW
    貢獻者: National Institute of Cancer Research
    摘要: To account for the accumulation of genomic alterations required for tumor progression, it has been suggested that the genomes of cancer cells are unstable and that this instability results from defective mutators (the "murator phenotype" theory). To examine the hypothesis that abnormal cell-cycle regulators act as the mutators contributing to genomic instability, the present study, based on primary tumor tissues from 71 patients with breast cancer, was performed to determine whether there was an association between aberrant expression of cell-cycle regulators (cyclin A, cyclin D 1, cyclin E, RBI, p21, and p27) and chromosomal instability. Comparative genomic hybridization was used to measure chromosomal changes, reflecting genomic instability in individual tumors, whereas immunohistochemistry was used to detect aberrant expression of cell-cycle regulators. Overexpression of cyclin D I was found to be significantly correlated with increased chromosomal instability (defined as harboring more than 7 chromosomal changes), with 63% of tumors overexpressing and 27% of tumors not overexpressing, with cyclin D I showing chromosomal instability (P < 0.05). Interestingly, this relationship was independent of cell outgrowth (as detected by the proliferation marker Ki-67) and was particularly significant in tumors not expressing p27 or in tumors with detectable RBI. These results suggest that cyclin D I plays an alternative role in the regulation of genomic stability. (C) 2002 Wiley-Liss, Inc.
    關鍵詞: Oncology;Genetics & Heredity
    日期: 2002-07
    關聯: Genes Chromosomes and Cancer. 2002 Jul;34(3):276-284.
    Link to: http://dx.doi.org/10.1002/gcc.10072
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1045-2257&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000175842700003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036107422
    顯示於類別:[吳成文(1996-2008)] 期刊論文

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