國家衛生研究院 NHRI:Item 3990099045/2664
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2664


    Title: Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma
    Authors: Torng, PL;Lee, YCG;Huang, CYF;Ye, JH;Lin, YS;Chu, YW;Huang, SC;Cohen, P;Wu, CW;Lin, CT
    Contributors: National Institute of Cancer Research
    Abstract: Metastasis and invasion occur in the majority of epithelial ovarian carcinoma at diagnosis. To delineate the molecular signature in ovarian cancer invasion, we established and characterized a human ovarian endometrioid carcinoma (EC) cell line OVTW59-P0 and its invasion-related sublines (P1-P4, in the order of increasing invasive activity). P4 showed faster migration and larger xenograft formation with metastasis than P0. By microarray analysis of different gene expression among P0-P4 sublines, one group of gene was found negatively correlated with cancer invasion. Among these genes, IGFBP-3 was identified as one of the most remarkably suppressed gene that showed lower gene expression in P4 than P0. Re-expression of IGFBP-3 in P4 effectively inhibited cell migration, invasion and metastasis, but did not affect cell proliferation. In 35 patients with EC tumors, low IGFBP-3 expression correlated clinically with higher tumor grade, advanced stage and poor survival. Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC.
    Keywords: Biochemistry & Molecular Biology;Oncology;Cell Biology;Genetics & Heredity
    Date: 2008-04-03
    Relation: Oncogene. 2008 Apr;27(15):2137-2147.
    Link to: http://dx.doi.org/10.1038/sj.onc.1210864
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9232&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000254621300004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41649110046
    Appears in Collections:[Cheng-Wen Wu(1996-2008)] Periodical Articles
    [Chi-Ying F. Huang(2005-2007)] Periodical Articles

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