國家衛生研究院 NHRI:Item 3990099045/2608
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    题名: Modulation of YY1 activity by SAP30
    作者: Huang, NE;Lin, CH;Lin, YS;Yu, WCY
    贡献者: National Institute of Cancer Research
    摘要: Yin Yang 1 (YY1) is a highly conserved and multifunctional transcription factor. The diverse activities of YY1 are regulated and sometimes modified by interaction with various other proteins. By using a yeast two-hybrid screening system, SAP30 was identified as a protein that associates with YY1 and it is able to enhance YY1-mediated repression in a dose-dependent manner. SAP30 is a 30 kDa nuclear protein and is a component of the human histone deacetylase complex. In this study, the interaction of SAP30 and YY1 was confirmed both by in vitro and in vivo assays. The interaction domains between YY1 and SAP30 were mapped to the C-terminal segment of YY1 (295-414) and the C-terminal 91 amino acid region of SAP30. The observation that YY1, SAP30, and HDAC1 form a complex in vivo provides evidence that YY1 also recruits HDAC1 indirectly via its binding to SAP30. These results describe a novel mechanism for YY1-mediated repression. (C) 2003 Elsevier Science (USA). All rights reserved.
    关键词: Biochemistry & Molecular Biology;Biophysics
    日期: 2003-06-20
    關聯: Biochemical and Biophysical Research Communications. 2003 Jun;306(1):267-275.
    Link to: http://dx.doi.org/10.1016/S0006-291X(03)00966-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000183676900043
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037716515
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