國家衛生研究院 NHRI:Item 3990099045/2607
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    题名: Linkage of CD40L to a self-tumor antigen enhances the antitumor immune responses of dendritic cell-based treatment
    作者: Chen, HW;Huang, HI;Lee, YP;Chen, LL;Liu, HK;Cheng, ML;Tsai, JP;Tao, MH;Ting, CC
    贡献者: National Institute of Cancer Research;Vaccine Research and Development Center
    摘要: CD40-CD40 ligand (CD40L) interaction is an important costimulatory signal in the interaction between T cells and antigen-presenting cells (APC). In the present study, we determined whether the linkage of CD40L to the tumor-specific idiotype (Id) derived from a murine B-cell lymphoma, 38C13, could enhance its immunogenicity when presented by dendritic cells (DC). We showed that bone marrow-derived DC pulsed with Id-CD40L upregulated the expression of CD40, CD80, CD86, and major histocompatibility complex (MHC) class II molecules with the increased production of interleukin-12 (IL-12). Mice immunized with DC loaded with Id-CD40L showed high levels of anti-Id antibody response of both IgG2a and IgG1 isotypes. In addition, nylon wool-enriched T cells from these immunized mice showed a tumor-specific T-cell proliferative response upon stimulation with Id protein. Mice immunized with DC pulsed with Id alone failed to show any of these immune responses. Immunization with DC pulsed with Id-CD40L showed increased resistance to the challenge by 38C13 tumor, and tumor growth was significantly retarded. Together, these results show that linkage of CD40L to a self-tumor antigen enhances the anti-tumor immune response in DC-based treatment.
    关键词: Oncology;Immunology
    日期: 2002-08
    關聯: Cancer Immunology Immunotherapy. 2002 Aug;51(6):341-348.
    Link to: http://dx.doi.org/10.1007/s00262-002-0283-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-7004&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000177244100006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036301974
    显示于类别:[丁兆治(2000-2004)] 期刊論文
    [陳信偉] 期刊論文

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